For those constantly searching for their next favorite vintage, Six Senses Douro Valley might just have the answer. The very first resort that Six Senses has opened in Europe is set in a handsome 19th-century manor but features clean, cool, 21st-century interiors. The property is also surrounded by the oldest demarcated wine region in the world. Much of the food is grown in the eight hectares of organic gardens on the property, while the spa offers locally inspired, grape-based treatments. The resort’s interactive wine academy even allows its guests to dive into the winemaking process with some of Portugal’s leading winemakers, from grape-harvesting and stomping through to learning how to blend their own wine.